The National Road 222 (EN222) is one of the most beautiful roads in the world and is known for offering one of the best driving experiences for nature lovers. The road runs through the heart of the Douro Vinhateiro, a wine region in Portugal, and offers breathtaking views of the mountains, rivers and vineyards that surround the area.

If you have a road trip through the Douro in your plans, the EN222 is one of the most recommended routes to explore. Some 225 km long, the road starts in Vila Nova de Gaia and ends in Vila Nova de Foz Côa, passing through towns such as Resende, Régua, São João da Pesqueira and other popular tourist destinations along the way.

In this guide, you'll find everything you need to know to plan your trip along the EN222. From the best photo spots to the most recommended restaurants and accommodation, this comprehensive itinerary will help you make the most of your adventure on Portugal's most beautiful road.

Why take a road trip along the EN222?

The National Road 222 is one of the most beautiful roads in the world, with breathtaking views over the Douro River and the vineyards that surround it. A road trip along the EN222 is a unique experience that should not be missed by lovers of nature, history and culture. Here are some reasons why you should consider taking a road trip along the EN222:

  • Natural beauty: The landscape is spectacular, with green hills, terraced vineyards and the Douro River meandering through them.
  • Culture and history: The EN222 passes through many historic villages, such as Régua, Pinhão and Resende, where you can find ancient monuments, churches and museums.
  • Gastronomy: The Douro region is famous for its wines, but also for its gastronomy. There are many restaurants along the EN222 that serve traditional Portuguese dishes, such as cozido à portuguesa and bacalhau.
  • Adventure: There are many outdoor activities to do in the Douro region, such as hiking, boating, cycling and even hot air balloon rides.

A road trip along the EN222 is a unique opportunity to get to know the natural beauty and culture of the Douro region. Don't miss the chance to take this unforgettable trip!

What to visit on the EN222?

The National Road 222 is one of the most beautiful roads in the world and offers breathtaking views of the Douro. If you're planning a road trip through the Douro, here are some suggestions on what to visit on the EN222.


There are several viewpoints along the EN222, which offer panoramic views of the Douro. The São Leonardo de Galafura viewpoint is one of the most famous and offers incredible views of the Douro valley. Other popular viewpoints are the Miradouro de São Salvador do Mundo and the Miradouro de Nossa Senhora dos Remédios.


The Douro region is famous for its wines, and there are many wineries along the EN222 that offer wine tastings and guided tours. Some of the most popular wineries are Quinta do Vallado, Quinta do Crasto and Quinta do Panascal.

Cities and towns

The EN222 passes through several charming cities and towns. Lamego is a historic city with an impressive cathedral and a medieval castle. Pinhão is a picturesque village that is home to several wineries and offers boat trips along the Douro River. Peso da Régua is another city worth visiting, with an iconic bridge over the Douro River and several museums dedicated to wine.

Historical monuments and sites

The EN222 passes several interesting historical monuments and sites. The Monastery of São João de Tarouca is a 12th century Cistercian monastery that is one of the oldest in Portugal. Casa de Mateus is an 18th century baroque mansion that is famous for its gardens and vineyards. The Côa Museum is a rock art museum that houses some of the oldest rock paintings in Europe.

Tips for a road trip along the EN222

When to go

The best time to take a road trip along the EN222 is between April and May, when the weather is milder and the vineyards are in full bloom. The grape harvest takes place in September and October. You can enjoy various harvest activities, stomping on the grapes, at various quintas throughout the Douro. However, it's important to remember that during the summer months, the road can be busier, which can make the journey a little longer.

Where to stay

There are various accommodation options along the EN222, from hotels and guesthouses to country houses and campsites. It is recommended to book in advance, especially during the summer months, to ensure availability.


Régua | Douro Palace Hotel Resort & Spa
Pinhão | The Vintage House - Douro
Lamego | Casa de Santo António de Britiande

What to bring

Some important items to take on a road trip along the EN222 include:

  • Sunscreen and a hat to protect yourself from the sun
  • Water and snacks to stay hydrated
  • A map or GPS to help with navigation
  • A camera to capture the stunning landscapes

Safety on the road

It is important to remember that the EN222 is a winding, narrow road with many bends and steep climbs. It is recommended that you drive carefully and respect the speed limits. In addition, it is important to keep an eye out for other drivers and pedestrians on the road.